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    Полное описание

    Phosphodiesterases as Drug Targets : сборник / editor.: S. Francis [et al.] ; edited by Sharron H. Francis, Marco Conti, Miles D. Houslay. - Berlin ; Heidelberg : Springer, 2011. - on-line. - (Handbook of Experimental Pharmacology ; vol. 204). - URL: http://dx.doi.org/10.1007/978-3-642-17969-3. - Загл. с экрана. - ISBN 978-3-642-17969-3. - Текст : электронный.

    ГРНТИ УДК
    31.2757
    3458
    6259
    7660
    61

    Рубрики:
    medicine
    pharmacology
    medicinal chemistry
    proteins
    enzymology
    posttranslational modification
    cell physiology
    biomedicine
    pharmacology/Toxicology
    medicinal Chemistry
    protein Structure
    enzymology
    posttranslational Modification
    cell Physiology
    Превентивная и персонализированная медицина, обеспечение здорового долголетия

    Аннотация: Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
    Доп. точки доступа:
    Francis, S.\editor.\
    Conti, M.\editor.\
    Houslay, M.\editor.\

    http://dx.doi.org/10.1007/978-3-642-17969-3


    Держатели документа:
    Государственная публичная научно-техническая библиотека России : 123298, г. Москва, ул. 3-я Хорошевская, д. 17 (Шифр в БД-источнике (KATBW): -633056415)

    Шифр в сводном ЭК: c40c1e4ed8277b1872ffc47468578417



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