Полное описание

Phosphodiesterases as Drug Targets : сборник / edited by Sharron H. Francis, Marco Conti, Miles D. Houslay. - Electronic text data. - Berlin ; Heidelberg : Springer, 2011. - (Handbook of Experimental Pharmacology, ISSN 0171-2004 ; vol. 204). - URL: http://dx.doi.org/10.1007/978-3-642-17969-3. - Загл. с экрана. - ISBN 978-3-642-17969-3. - DOI 10.1007/978-3-642-17969-3. - Текст : электронный.

ГРНТИ	УДК
61.45	615.012/.014

Рубрики:
medicine
pharmacology
medicinal chemistry
proteins
enzymology
posttranslational modification
cell physiology
biomedicine
pharmacology/Toxicology
medicinal Chemistry
protein Structure
enzymology
posttranslational Modification
cell Physiology

Аннотация: Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Доп. точки доступа:
Francis, S.\editor.\
Conti, M.\editor.\
Houslay, M.\editor.\

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