Полное описание

Davidovich, C. Targeting Functional Centers of the Ribosome / by Chen Davidovich. - Electronic text data. - Berlin ; Heidelberg : Springer, 2011. - (Springer Theses). - URL: http://dx.doi.org/10.1007/978-3-642-16931-1. - Загл. с экрана. - ISBN 978-3-642-16931-1. - DOI 10.1007/978-3-642-16931-1. - Текст : электронный.
Содержание:
Introduction -- Methods -- Results -- Discussion.

ГРНТИ	УДК
31.27	57
34	58
62	59
76	60
	61

Рубрики:
life sciences
organic chemistry
nucleic acids
proteins
life Sciences
nucleic Acid Chemistry
protein Science
organic Chemistry

Аннотация: This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.

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