Полное описание

Ohta, Y. Copper-Catalyzed Multi-Component Reactions : synthesis of Nitrogen-Containing Polycyclic Compounds / by Yusuke Ohta. - Electronic text data. - Berlin ; Heidelberg : Springer Berlin Heidelberg, 2011. - (Springer Theses). - URL: http://dx.doi.org/10.1007/978-3-642-15473-7. - Загл. с экрана. - ISBN 978-3-642-15473-7. - DOI 10.1007/978-3-642-15473-7. - Текст : электронный.

ГРНТИ	УДК
31.21.25	547.6:542.91(043)

Рубрики:
chemistry
organic chemistry
medicinal chemistry
chemistry
organic Chemistry
medicinal Chemistry

Аннотация: A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.

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